If you are using a screen magnifier:No adjustments needed. You may like the Arduino O&M post for more details on the smaller parts of the board.
If you are using a screen reader:
- If you are using OS X, VoiceOver has been reported to work with the Arduino Integrated Development Environment (IDE) without modification.
- If you are using Windows, see this post about setting up the software on Windows.
- If you are using Linux, the Windows setup post may be helpful but we do not have further details at this time.